Bioactive flavonoids from Kaempferia parviflora

Yenjai, Chavi; Prasanphen, Khanchara; Daodee, Supawadee; Wongpanich, Varima; Kittakoop, Prasat

https://doi.org/10.1016/j.fitote.2003.08.017

Abstract

Nine flavonoids (1–9) have been isolated from Kaempferia parviflora. Among these, 5,7,4'-trimethoxyflavone (8) and 5,7,3',4'-tetramethoxyflavone (9) exhibited antiplasmodial activity against Plasmodium falciparum, with IC50 values of 3.70 and 4.06 µg/ml, respectively. 3,5,7,4'-Tetramethoxyflavone (7) and compound 8 possessed antifungal activity against Candida albicans with respective IC50 values of 39.71 and 17.63 µg/ml, and also showed mild antimycobacterial activity with the minimum inhibitory concentrations (MIC) of 200 and 50 µg/ml, respectively. However, none of the isolated compounds demonstrated cytotoxicity against KB, BC and NCI-H187 cell lines.

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