Adaptogenic-active components from Kaempferia parviflora rhizomes

Pripdeevech, Patcharee; Pitija, Kitsada; Rujjanawate, Chaiyong; Pojanagaroon, Sermsakul; Kittakoop, Prasat; Wongpornchai, Sugunya

https://doi.org/10.1016/j.foodchem.2011.11.025

Abstract

Kaempferia parviflora rhizome extracts obtained by maceration with hexane, chloroform, methanol, and ethanol were screened for their adaptogenic activities using swimming tests of mice. The effective adaptogenic extract dose was 500 mg/kg of body weight and was given orally once a day. Crude hexane extract showed significantly shorter mouse immobilisation time than those of the other and control extracts. This crude hexane extract was separated into three fractions by column chromatography. Among these fractions, the fraction rich in terpenoids possessed the highest adaptogenic activity and was comparable to that of the crude ginseng root powder used as a reference control. Therefore, terpenes contained in this fraction could be attributed to the decrease in exhaustion during the swimming of mice. There was no effect on body weight, heart, liver, kidneys, and adrenal glands of the mice. Chemical characterisation of this adaptogenic-active fraction by NMR and GC–MS showed germacene D, ß-elemene, a-copaene, and E-caryophyllene as major constituents. Accordingly, these terpenes are considered the adaptogenic agents of K. parviflora rhizomes.

References:

Corbin, Jackie D; Francis, Sharron H; Webb, David J (2002) Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology. Volume 60, Issue 2, Supplement 2, August 2002, Pages 4-11. https://doi.org/10.1016/S0090-4295(02)01686-2

Essayan, D.M. (1999) Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation. Biochemical Pharmacology Volume 57, Issue 9, 1 May 1999, Pages 965-973. https://doi.org/10.1016/S0006-2952(98)00331-1

Ko, Wun-Chang; Shih, Chwen-Ming; Lai, Ya-Hsin; Chen, Jun-Hao; Huang, Hui-Lin (2004) Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure activity relationships. Biochemical Pharmacology Volume 68, Issue 10, 15 November 2004, Pages 2087-2094. https://doi.org/10.1016/j.bcp.2004.06.030

Shin, Hye Joo; Ja Kim, Hyoung; Kwak,Jong Hwan; Chun, Hyung Ok; Kim, Je Hak Park, Hokoon; Kim, Dong Hyun; Lee, Yong Sup (2002) A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorganic & Medicinal Chemistry Letters Volume 12, Issue 17, 2 September 2002, Pages 2313-2316. https://doi.org/10.1016/S0960-894X(02)00401-8

Sonnenburg, William K.; Rybalkin, Sergei D.; Bornfeldt, Karin E.; Kwak, Keith S.; Rybalkina, Irina G.; Beavo, Joseph A. (1998) Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases. Methods Volume 14, Issue 1, January 1998, Pages 3-19. https://doi.org/10.1006/meth.1997.0561

Sutthanut, K.; Sripanidkulchai, B.; Yenjai, C. ; Jay, M. (2007) Simultaneous identification and quantitation of 11 flavoid constituents in Kaempferia parviflora by gas chromatography. Journal of Chromatography A Volume 1143, Issues 1–2, 2 March 2007, Pages 227-233

Jaipetch, Tharworn; Reutrakul, Vichai; Tuntiwachwuttikul, Pittaya; Santisuk, Thawatchai (1983) Flavonoids in the black rhizomes of Boesenbergia pandurataPhytochemistry. Volume 22, Issue 2, 1983, Pages 625-626. https://doi.org/10.1016/0031-9422(83)83075-1

Matsuda, Hisashi; Tewtrakul, Supinya; Morikawa, Toshio; Nakamura, Akihiko; Yoshikawa, Masayuki (2004) Anti-allergic principles from Thai zedoary: structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-? and IL-4 in RBL-2H3 cells. Bioorganic & Medicinal ChemistryBioorganic & Medicinal Chemistry Volume 12, Issue 22, 15 November 2004, Pages 5891-5898. https://doi.org/10.1016/j.bmc.2004.08.027

Nakata, Yoshihiro; Hide, Izumi (1998) Calcium signaling and protein kinase C for TNF-alpha secretion in a rat mast cells. Life Sciences Volume 62, Issues 17–18, 27 March 1998, Pages 1653-1657. https://doi.org/10.1016/S0024-3205(98)00123-4

Patanasethanont, Denpong; Nagai, Junya; Yumoto, Ryoko; Murakami, Teruo; Sutthanut, Khaetthareeya; Sripanidkulchai, Bung-orn; Yenjai, Chavi; Takano, Mikihisa (2007) Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. Journal of Pharmaceutical Sciences Volume 96, Issue 1, January 2007, Pages 223-233. https://doi.org/10.1002/jps.20769

Rujjanawate, C.; Kanjanapothi, D.; Amornlerdpison, D. ; Pojanagaroon, S. (2005)Anti-gastric ulcer effect of Kaempferia parviflora. Journal of Ethnopharmacology Volume 102, Issue 1, 31 October 2005, Pages 120-122. https://doi.org/10.1016/j.jep.2005.03.035

Tewtrakul, Supinya; Subhadhirasakul, Sanan (2007) Anti-allergic activity of some selected plants in the Zingiberaceae family Journal of Ethnopharmacology Volume 109, Issue 3, 12 February 2007, Pages 535-538 https://doi.org/10.1016/j.jep.2006.08.010

Kitagawa, Hisato; Fujiwara, Motohatsu; Osumi, Yoshitsugu (1979) Effect of water immersion stress on gastric secretion and mucosal blood flow in ratsGastroenterology. Volume 77, Issue 2, August 1979, Pages 298-302. https://doi.org/10.1016/0016-5085(79)90281-6

Lukie, Bryan E.; Forstner, Gordon G. (1972) Synthesis of intestinal glycoproteins. Incorporation of [1-14C] glucosamine. Biochimica et Biophysica Acta (BBA) - General Subjects. Volume 261, Issue 2, 29 February 1972, Pages 353-364. https://doi.org/10.1016/0304-4165(72)90059-1

Yenjai, Chavi; Prasanphen, Khanchara; Daodee, Supawadee; Wongpanich, Varima; Kittakoop, Prasat (2004) Bioactive flavonoids from Kaempferia parviflora.Fitoterapia Volume 75, Issue 1, January 2004, Pages 89-92. https://doi.org/10.1016/j.fitote.2003.08.017